Megan Mullally and Rob Lowe have been friends for decades, but that didn’t stop Mullally from hitting back at Lowe after he made a joke about her on his new Netflix show.

In an episode of “The Lowe Files,” Lowe and his co-host, his son, Owen Lowe, visited the set of the hit sitcom “Will & Grace,” where Mullally starred as Karen Walker. During the visit, Lowe made a joke about Mullally’s character, saying, “Karen Walker is the worst person in the history of television.”

Mulally was not amused by the joke, and she took to Twitter to express her displeasure. “Rob Lowe, how could you?” she tweeted. “I thought we were friends.”

Lowe responded to Mullally’s tweet with an apology, saying, “I’m so sorry, Megan. I was just trying to be funny. I didn’t mean to hurt your feelings.”

Mulally accepted Lowe’s apology, and the two friends appear to have patched things up. However, the incident has sparked a debate on social media about whether it’s ever okay to make jokes about friends.

Some people believe that it’s perfectly fine to make jokes about friends, as long as they’re in good fun. Others believe that it’s never okay to make jokes at the expense of others, even if they’re friends.

Ultimately, it’s up to each individual to decide what they’re comfortable with. However, it’s important to be mindful of the fact that even jokes that are meant to be funny can sometimes hurt people’s feelings.