colitis-is-made-worse-by-a-dysbiotic-gut-microbiome-in-childhood

An ongoing digestive condition called inflammatory bowel disease (IBD) results in intestinal inflammation. There are a number of factors that can induce IBD, despite the fact that the exact etiology is not yet recognized. These elements are influenced by environment, immune system, genetics, and age. Dysbiosis of the gut’s microbes is one of the main causes of IBD manifestation.

Low oxygen levels and a wide variety of obligatory anaerobes are characteristics of a healthy gut. In contrast, people with IBD had elevated levels of nitrogen and reactive oxygen species (ROS). Inflammation of the digestive tract causes the colon to become more oxygenated, which causes an imbalance in the populations of aerobic and anaerobic bacteria.

Prior studies have demonstrated how obligate anaerobes, like Bifidobacterium and Clostridium butyricum, and their metabolites impact the intestinal environment in IBD. As was already mentioned, IBD patients have a gut microbial imbalance that has been linked to higher and lower levels of facultative anaerobes.

Plasmalogens are a typical type of ether lipid that is found in both anaerobic animals and bacteria. These are involved in membrane structure, ROS defense, and signaling. in spite of although the bulk of the bacteria in the gut microbiome have been associated with plasmalogen synthase (pls), little is known about the bacteria that produce this enzyme.

Recently, facultative aerobic and anaerobic bacteria were discovered to contain plasmalogens. To find potential targets for treatment, it is important to better understand the role of bacterial communities of plasmalogen-positive species (pls [PlsA/R]-positive) in gut inflammatory disorders.